Pair Name	Platycodin D, Cetuximab
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	MMP7	hsa4316
	Down-regulation	Expression	MYC	hsa4609
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
	Caco-2	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0025
In Vivo Model	HT29 and CaCo2 cells were trypsinized and injected into the tail vein of nu/nu nude mice with a concentration of 2×10⁵/0.2 ml to establish a model for metastatic lung tumors.
Result	Our findings provide a potential strategy to inhibit CRC metastasis during cetuximab therapy by addition of platycodin D.